Accumulation of mucus contributes to airflow obstruction and predisposes the patient to chronic respiratory infection, which can in turn lead to bronchiectasis and numerous other complications throughout the body.
Because CF is caused by an inborn mutation, symptoms of disease typically manifest in childhood. Symptoms of CF include: chronic sinusitis, nasal obstruction, nasal polyps, and cough.
Over time, persistent cough produces thick, greenish sputum that may also contain pus.
Survival has improved with new therapeutic techniques, and patient life expectancy has increased from late childhood to approximately 40 years.
Review Date:
2/17/2024 Reviewed By: Charles I. Schwartz, MD, FAAP, Clinical Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, General Pediatrician at PennCare for Kids, Phoenixville, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. |