Salivary gland biopsy

Definition

Salivary gland biopsy is the removal of cells or a piece of tissue from a salivary gland for exam.

Alternative Names

Biopsy - salivary gland

How the Test is Performed

You have several pairs of salivary glands that drain into your mouth:

One type of salivary gland biopsy is a needle biopsy.

A biopsy can also be done to:

An open surgical biopsy of the minor salivary glands in the lips or the parotid gland can also be performed to diagnose diseases such as Sjögren syndrome.

How to Prepare for the Test

There is no special preparation for a needle biopsy. However, you may be asked not to drink or eat anything for a few hours before the test.

For surgical removal of a tumor, preparation is the same as for any major surgery. You will not be able to eat anything for 6 to 8 hours before the surgery.

How the Test will Feel

With a needle biopsy, you may feel some stinging or burning if a local numbing medicine is injected.

You may feel pressure or mild discomfort when the needle is inserted. This should only last for 1 or 2 minutes.

The area may feel tender or be bruised for a few days after the biopsy.

The biopsy for Sjögren syndrome requires an injection of the anesthetic in the lip or in the front of the ear. You will have stitches where the tissue sample was removed.

Why the Test is Performed

This test is done to find the cause of abnormal lumps or growths of the salivary glands. It is also done to diagnose Sjögren syndrome.

Normal Results

The salivary gland tissue is normal.

What Abnormal Results Mean

Abnormal results may indicate:

Risks

Risks from this procedure include:

References

Miloro M, Kolokythas A. Diagnosis and management of salivary gland disorders. In: Hupp JR, Ellis E, Tucker MR, eds. Contemporary Oral and Maxillofacial Surgery. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 21.

Orlowski HLP, Miller-Thomas M. Diagnostic imaging and fine-needle aspiration of the salivary glands. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 82.



Review Date: 3/1/2023
Reviewed By: Josef Shargorodsky, MD, MPH, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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