Asymptomatic HIV infection
Definition
Asymptomatic HIV infection is the second stage of HIV/AIDS. During this stage, there are no symptoms of HIV infection. This stage is also called chronic HIV infection or clinical latency.
During this stage, the virus keeps multiplying in the body and the immune system slowly weakens, but the person has no symptoms. How long this stage lasts depends on how quickly the HIV virus copies itself, and how the person's genes affect the way the body handles the virus.
Some people may have symptoms and worsening immune function within a few years after the original infection. Others can go 10 years or longer without symptoms (not common).
References
Kleinpeter AP, Freed EO. Human immunodeficiency viruses. In: Blaser MJ, Cohen JI, Holland SM, et al, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 10th ed. Philadelphia, PA: Elsevier; 2026:chap 120.
Quinn TC, Chang LW. Acute clinical manifestations and diagnosis of HIV. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 355.
US Department of Health & Human Services. HIV.gov website. What are HIV and AIDS? www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids. Updated September 17, 2025. Accessed October 13, 2025.
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Review Date:
5/12/2025 Reviewed By: Jatin M. Vyas, MD, PhD, Roy and Diana Vagelos Professor in Medicine, Columbia University Vagelos College of Physicians and Surgeons, Division of Infectious Diseases, Department of Medicine, New York, NY. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update 10/13/2025. |
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