Aortic regurgitation
Definition
Aortic regurgitation is a heart valve disease in which the aortic valve does not close tightly. This allows blood to flow from the aorta (the largest blood vessel) into the left ventricle (a chamber of the heart).
Alternative Names
Aortic valve prolapse; Aortic insufficiency; Heart valve - aortic regurgitation; Valvular disease - aortic regurgitation; AI - aortic insufficiency
Causes
Any condition that prevents the aortic valve from closing completely can cause this problem. When the valve does not close all the way, some blood comes back each time the heart beats.
When a large amount of blood comes back, the heart must work harder to force out enough blood to meet the body's needs. The left lower chamber (left ventricle) of the heart widens (dilates) and the heart beats very strongly (bounding pulse). Over time, the heart becomes less able to supply enough blood to the body.
In the past, rheumatic fever was the main cause of aortic regurgitation. The use of antibiotics to treat strep infections has made rheumatic fever less common. Therefore, aortic regurgitation is more commonly due to other causes. These include:
- Ankylosing spondylitis
- Aortic dissection
- Congenital (present at birth) valve problems, such as bicuspid valve
- Endocarditis (infection of the heart valves)
- High blood pressure
- Marfan syndrome
- Reiter syndrome (also known as reactive arthritis)
- Syphilis
- Systemic lupus erythematosus
- Trauma to the chest
Aortic insufficiency is most common in men between the ages of 30 and 60.
Symptoms
The condition often has no symptoms for many years. Symptoms may come on slowly or suddenly. They may include:
- Bounding pulse
- Chest pain similar to angina (rare)
- Fainting
- Fatigue
- Palpitations (sensation of the heart beating)
- Shortness of breath with activity or when lying down
- Waking up short of breath after falling asleep
- Swelling of the feet, legs, or abdomen
- Uneven, rapid, racing, pounding, or fluttering pulse
- Weakness that is more likely to occur with activity
Exams and Tests
Signs may include:
- Heart murmur that can be heard through a stethoscope
- Very forceful beating of the heart
- Bobbing of the head in time with the heartbeat
- Hard pulses in the arms and legs
- Low diastolic blood pressure
- Signs of fluid in the lungs
Aortic regurgitation may be seen on tests such as:
- Aortic angiography
- Echocardiogram -- ultrasound examination of the heart
- Left heart catheterization
- MRI or CT scan of the heart
- Transthoracic echocardiogram (TTE) or transesophageal echocardiogram (TEE)
A chest x-ray may show swelling of the left lower heart chamber.
Lab tests cannot diagnose aortic insufficiency. However, they may help check for other causes of symptoms.
Treatment
You may not need treatment if you have no symptoms or only mild symptoms. However, you will need to see a health care provider for regular exams and echocardiograms.
Diuretics (water pills) or other types of medicines may be prescribed for symptoms of heart failure.
In the past, most people with heart valve problems were given antibiotics before dental work or an invasive procedure, such as colonoscopy. The antibiotics were given to prevent an infection of the damaged heart. However, antibiotics are now used much less often.
You may need to limit activity that requires more work from your heart. Talk to your provider.
Surgery to repair or replace the aortic valve corrects aortic regurgitation. The decision to have aortic valve replacement depends on your symptoms and the condition and function of your heart. There is increasing interest in a minimally invasive procedure in which a replacement valve is implanted via catheter. This is similar to a procedure traditionally done in people with aortic stenosis. This option may become more common in the future.
You may also need surgery to repair the aorta if it is enlarged.
Outlook (Prognosis)
Surgery can cure aortic insufficiency and relieve symptoms, unless you develop heart failure or other complications. People with angina or congestive heart failure due to aortic regurgitation do poorly without treatment.
Possible Complications
Complications may include:
- Abnormal heart rhythms
- Heart failure
- Infection in the heart
When to Contact a Medical Professional
Contact your provider if:
- You have symptoms of aortic regurgitation.
- You have aortic insufficiency and your symptoms worsen or new symptoms develop (especially chest pain, difficulty breathing, or swelling).
Prevention
Blood pressure control is very important if you are at risk for aortic regurgitation.
References
Bonow RO, Nishimura RA. Aortic Regurgitation. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 73.
Carabello BA, Kodali S. Valvular heart disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 60.
Leon MB, Mack MJ. Transcatheter Aortic Valve Replacement. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 74.
Writing Committee Members, Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Thorac Cardiovasc Surg. 2021;162(2):e183-e353. PMID: 33972115 pubmed.ncbi.nlm.nih.gov/33972115/.
Reviewed By: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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