Amylase is an enzyme that helps digest carbohydrates. It is made in the pancreas and the glands that make saliva. When the pancreas is diseased or inflamed, it releases increased amounts of amylase into the blood.
A test can be done to measure the level of this enzyme in your blood.
Amylase may also be measured with a urine amylase test.
Pancreatitis - blood amylase
A blood sample is taken from a vein.
No special preparation is needed. However, you should avoid alcohol before the test. The health care provider may ask you to stop taking drugs that may affect the test. Do not stop taking any medicines without first talking to your provider.
Drugs that can increase amylase measurements include:
You may feel slight pain or a sting when the needle is inserted to draw blood. Afterward, there may be some throbbing.
This test is most often used to diagnose or monitor acute pancreatitis. It may also detect some digestive tract problems.
The test may also be done for the following conditions:
The normal range is 40 to 140 units per liter (U/L) or 0.38 to 1.42 microkat/L (µkat/L).
Normal value ranges may vary slightly among different laboratories. Some laboratories use different measurement methods. Talk to your provider about the meaning of your test results.
Increased blood amylase level may occur due to:
Decreased amylase level may occur due to:
Slight risks from having blood drawn may include:
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Forsmark CE. Pancreatitis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 135.
Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.
Vege SS. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 58.
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.