Antibody titer is a laboratory test that measures the level of antibodies in a blood sample.
Titer - antibodies; Serum antibodies
No special preparation is necessary for this test.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or slight bruising. This soon goes away.
The antibody level (titer) in the blood tells your health care provider whether or not you have been exposed to an antigen, or something that the body thinks is foreign. The body uses antibodies to attack and remove foreign substances.
In some situations, your provider may check your antibody titer to see if you had an infection in the past (for example, chickenpox) or to decide which vaccines you need.
The antibody titer is also used to determine:
Normal values depend on the antibody being tested.
If the test is being done to look for antibodies against your own body tissues, the normal value would be zero or negative. In some cases, a normal level is below a specific number.
If the test is being done to see if a vaccine fully protects you against a disease, the normal result depends on the specific value for that immunization.
Negative antibody tests can help rule out certain infections.
Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.
Abnormal results depend on which antibodies are being measured.
Abnormal results may be due to:
There is little risk involved with having your blood taken. Veins vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Risks associated with having blood drawn are slight, but may include:
Kroger AT, Pickering LK, Mawle A, Hinman AR, Orenstein WA. Immunization. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 316.
McPherson RA, Riley RS, Massey HD. Laboratory evaluation of immunoglobulin function and humoral immunity. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. Philadelphia, PA: Elsevier; 2017:chap 46.
Reviewed By: Stuart I. Henochowicz, MD, FACP, Clinical Professor of Medicine, Division of Allergy, Immunology, and Rheumatology, Georgetown University Medical School, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.