Chronic lymphocytic leukemia (CLL) is cancer of a type of white blood cells called lymphocytes. These cells are found in the bone marrow and other parts of the body. Bone marrow is the soft tissue in the center of bones that helps form all blood cells.
CLL causes a slow increase in a certain type of white blood cells called B lymphocytes, or B cells. Cancer cells spread through the blood and bone marrow. CLL can also affect the lymph nodes or other organs such as the liver and spleen. CLL eventually can cause the bone marrow to lose its function.
CLL; Leukemia - chronic lymphocytic (CLL); Blood cancer - chronic lymphocytic leukemia; Bone marrow cancer - chronic lymphocytic leukemia; Lymphoma - chronic lymphocytic leukemia
The cause of CLL is unknown. There is no link to radiation. It is unclear if certain chemicals can cause CLL. Exposure to Agent Orange during the Vietnam War has been linked to a slight increased risk for developing CLL.
CLL usually affects older adults, especially those over age 60. People under age 45 rarely develop CLL. CLL is more common in whites than in other ethnic groups. It is more common in men than in women. Some people with CLL have family members with the disease.
Symptoms usually develop slowly. CLL often does not cause symptoms at first. It may be found by blood tests done in people for other reasons.
Symptoms of CLL may include:
The health care provider will perform a physical exam and ask about your symptoms.
Tests to diagnose CLL may include:
People with CLL usually have a high white blood cell count.
Tests that look at changes in the DNA inside the cancer cells may also be done. Results from these tests and from staging tests help your provider determine your treatment.
If you have early stage CLL, your provider will just monitor you closely. Treatment is not generally given for early-stage CLL, unless you have:
Targeted therapy and sometimes chemotherapy are used to treat CLL. Your provider will determine which type of medicines are right for you.
Blood transfusions or platelet transfusions may be required if blood counts are low.
Bone marrow or stem cell transplantation may be used in younger people with advanced or high-risk CLL. A transplant is the only therapy that offers a potential cure for CLL, but it also has risks. Your provider will discuss the risks and benefits with you.
You and your provider may need to manage other concerns during your leukemia treatment, including:
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Your provider can discuss with you the outlook of your CLL based on its stage and how well it responds to treatment.
Complications of CLL and its treatment may include:
Contact a provider if you develop enlarged lymph nodes or unexplained fatigue, bruising, excessive sweating, or weight loss.
Awan FT, Byrd JC. Chronic lymphocytic leukemia. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff''s Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 99.
National Cancer Institute website. Chronic lymphocytic leukemia treatment (PDQ) - health professional version. www.cancer.gov/types/leukemia/hp/cll-treatment-pdq. Updated September 6, 2022. Accessed September 13, 2022.
National Comprehensive Cancer Network website. NCCN clinical practice guidelines in oncology. Chronic lymphocytic leukemia/small lymphocytic lymphoma. Version 3.2022. www.nccn.org/professionals/physician_gls/pdf/cll.pdf. Updated June 3, 2022. Accessed June 27, 2022.
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.