This test measures the levels of catecholamines in the blood. Catecholamines are hormones made by the adrenal glands. The three catecholamines are epinephrine (adrenaline), norepinephrine, and dopamine.
Catecholamines are more often measured with a urine test than with a blood test.
Norepinephrine - blood; Epinephrine - blood; Adrenaline - blood; Dopamine - blood
A blood sample is needed.
You will likely be told not to eat anything (fast) for 10 hours before the test. You may be allowed to drink water during this time.
The accuracy of the test can be affected by certain foods and medicines. Foods that can increase catecholamine levels include:
You should not eat these foods for several days before the test. This is especially true if both blood and urine catecholamines are to be measured.
You should also avoid stressful situations and vigorous exercise. Both can affect the accuracy of the test results.
Medicines and substances that can increase catecholamine measurements include:
Medicines that can decrease catecholamine measurements include:
If you take any of the above medicines, check with your health care provider before the blood test about whether you should stop taking your medicine.
When the needle is inserted to draw blood, some people feel slight pain. Others feel a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Catecholamines are released into the blood when a person is under physical or emotional stress. The main catecholamines are dopamine, norepinephrine, and epinephrine (which used to be called adrenalin).
The normal range for epinephrine is 0 to 140 pg/mL (764.3 pmol/L).
The normal range for norepinephrine is 70 to 1700 pg/mL (413.8 to 10048.7 pmol/L).
The normal range for dopamine is 0 to 30 pg/mL (195.8 pmol/L).
Note: Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
Higher-than-normal levels of blood catecholamines may suggest:
Additional conditions under which the test may be performed include multiple system atrophy.
There is little risk in having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
Chernecky CC, Berger BJ. Catecholamines - plasma. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:302-305.
Guber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 25.
Young WF. Adrenal medulla, catecholamines, and pheochromocytoma. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 215.
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.